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Laser Hemotherapy is irradiation of blood flowing in the blood vessels with laser light.

Laser Hemotherapy device uses low energy laser of specific wavelengths 650nm to illuminate the blood in radial artery at wrist and the inside of the nose (the nasal cavity). In this way, the light can effectively penetrate the thin layer of mucous membrane and skin to reach the rich blood flowing just below its surface, improving the blood properties. The low level laser light used stimulates the body to heal or restore its internal equilibrium (“homeostasis”).

Many scientific studies have been carried out to support the therapeutic effect of direct (as with Intravenous laser blood irradiation) and indirect (as with laser hemotherapy), particularly at several Russian, European and Chinese universities.

Theories on the Mechanisms

Laser hemotherapy works because of “bio stimulation” and photobiomodulation. A number of theories have been put forward on the mechanism of bio stimulation at cellular level from light illumination (or irradiation) of various forms. Most of the literature have been focused on the more widely practices of applying the light from outside of the body targeting selected areas of the body. Various theories explaining the mechanism have been proposed when blood in circulation is irradiated, either intravenously (injecting light into the vein – commonly practiced in Russia, Germany and several European countries) or through the skin, in the radial artery and mucosa of nasal cavity in our case.

Triggering ATP cycle

Harvard researcher, Hamblin, studied the activity of the cells upon exposure to certain low energy red light. He expounds the theory that tissues have photo reactive proteins that will eventually stimulate the production of adenosine tri phosphate (ATP). ATP stores cellular energy, which is then released for biochemical processes occurring inside the cell. This explanation is shared by many researchers in the field and is called as photobiomodulation.

Singlet oxygen and ROS   as “Redox Signaling”.

Hamblin also says that the absorption of the light packet, photon leads to the production of singlet oxygen, a reactive oxygen species (ROS) that is a “free radical”.

The theory based on the creation of singlet oxygen and ROS appears to have the most relevance for Laser hemotherapy. When we are physically hurt or ill in some way, the cellular damage and inflammation creates additional singlet oxygen molecules, which is a reactive oxygen species (ROS). The homeostasis is unsettled and the body is signaled to restore the balance by stimulating the immune response system, increasing blood flow to the distressed areas, repair DNA and regenerate cells, etc. In other words it gets stimulated into the healing process. During this restoration, damaged cells die (“cell apoptosis”). This signaling process that stimulates the restoration is now recognized as “Redox Signaling”.

 During this process, the ROS created act as Redox Signaling molecules. Eventually they create an anti oxidative effect. The body does not do anything differently than it normally does.

Cells exposed to light in the red spectrum as with laser hemotherapy device which has 650 nm laser light, mimics this response (but at controlled output energy level to avoid cellular damage).

The process also signals the body’s defense mechanism to activate the native antioxidants in the cells. Meanwhile at this low energy level, the potential for oxidative damage by singlet oxygen is exceeded by the antioxidative therapy that it stimulates.

During the process of Laser hemotherapy the blood cells through the radial artery at wrist and capillary network in the nasal cavity, the Redox Signaling molecules are created and distributed in the circulatory system throughout the body, hence spreading the anti oxidative effect systemically all over the body.

In the growing science of “photodynamic therapy” for cancer treatment, certain red light is used to generate singlet oxygen.  These singlet oxygen can be highly toxic (hence effective in attacking cancer tumor when combined with drugs), but at low doses, they are less excited and settle back into the original ground state relatively quickly.

Several researchers now adopt the view that the singlet oxygen influences the formation of ATP, which apart from contributing to the energy that drives activity, is also responsible for the healing of the body.

The anti-inflammation theory

The presence of RBC aggregation is found to be due to the presence of macromolecular proteins such as fibrinogen and globulin. Fibrinogen is the protein which is sensitive to inflammation and helps with the blood clotting function. It is a dominant factor in RBC aggregation. Since inflammation is caused by an illness or disorder, one can attribute the presence of blood aggregation to the presence of an illness or a disorder. Therefore when RBC aggregation occurs, it means that the subject is at least not in perfect health.

When inflammation is reduced through LLLT, the level of fibrinogen in the blood will also be reduced. As the result RBCs will be visibly disaggregated. Literature suggests that LLLT reduces inflammation through healing and regeneration actions, amongst which include:

  • stabilizing the cellular membranes ,
  • enhancing ATP production and
  • synthesis which contribute to cellular healing ,
  • vasodilatation (dilation of blood vessels) ,
  • acceleration of leukocyte and lymphocyte activities to remove damaged cellular components and allowing for more rapid repair , and
  • Helps regenerate blood capillaries.

There is also a recent study suggesting that LLLT illumination "decreases the amount of inflammation and accelerates the wound healing process by changing the expression of genes responsible for the production of inflammatory cytokines."

The photodissociation theory

Research has established that hemoglobin is a primary photo acceptor absorbing low-intensity laser radiation. The exposure of blood to this radiation causes clearly defined changes in the IR and visible absorption spectra of the blood and RBCs. These spectral changes arise as a result of partial photo dissociation (breaking down of chemical compounds with light) of hemoglobin-ligand (substance to bind biomolecules) complexes in the process of absorption of laser radiation. It is suggested that photo dissociation is a primary reaction that arises in blood exposed to a low-intensity laser radiation. This result is the disaggregation of aggregated RBC.

The transient local heating hypothesis

Upon contact with blood, a substantial amount of absorbed red light energy is converted to heat, which causes a local transient increase in the temperature of absorbing chromophores (molecules responsible for their colors). This local transient heating of absorbing molecules is different from the general heating of the whole cell, tissue and organism as commonly imagined. The local transient increase in temperature causes structural changes, and trigger biochemical activity that results in the disaggregation of RBC.

The negative surface charge theory

Some researchers suggest that LLLT raises and restores the negative surface charge of the RBCs, rebalancing the play with electrolytes, and restoring their natural state of the RBCs repelling each other.

The Russian scientist theorys

In discussing the mechanism of intranasal low intensity laser irradiation therapy, some researchers have suggested the mediation of bio stimulation through three alternative pathways involving:

  1. Blood irradiation (hemotherapy),
  2. Acupuncture points and
  3. Autonomic nervous system.

In hemotherapy, they mention that when diseases occur, the blood properties are not in homeostasis, and light-based bio stimulation would restore that.

There are several theories as to how LLLT would neutralize RBC aggregation. What matters is that LLLT is proven to succeed in disaggregating RBC. The ever increasing list of diseases that are benefitted with laser hemotherapy has helped to understand the disease process itself!


How we gain by using laser hemotherapy regularly?

  • As preventive medicine: Anybody can use it .The biostimulative effect of laser hemotherapy when used regularly will put the body’s mechanism continuously on alert. It is a preventive measure against viral infection because the immune system has been signaled to be on guard, stimulated by Redox Signaling.
  • Anti-aging: As we age, damaged cells and tissues are not repaired as efficiently as when we are young. These damaged cells begin to outnumber healthy cells, manifesting in visible aging, like wrinkles, etc and eventually leading to death.
  • Anti oxidative effect:  On top of activating the immune system, regular Redox Signaling also stimulates the release of superoxide dismutase (SOD). This enzyme is anti oxidative and neutralizes the continuous free radical and oxidative activities in the body. The effect makes the repair and replace, mechanism more efficient, delaying the aging process. Laser hemotherapy has been found to increase the SOD activity which helps to delay aging.
  • Healing: Numerous healing outcomes have been published with the use of low energy laser light. Most of these relate to light therapy applied from outside of the body. The various regulatory bodies have approved a number of these for pain management. Many countries have approved them for accelerated wound healing. The older intravenous method of blood irradiation is supported by many Russian studies for cardiovascular conditions such as high blood pressure, high cholesterol and atherosclerosis that often leads to stroke and heart attacks.


The concept of laser hemotherapy is still relatively new but the expected healing outcomes are supported by studies that mainly come out of China, Russia and many European countries. As the result, this therapy is officially government sanctioned and private companies are certified to sell the devices. An estimated 10 million of these devices have now been sold and widely used by hospitals to support rehabilitation in these countries